A science fiction story for recombinant virus geeks and the rest of us. Because Patty is nothing if not a medical RPer.

A science fiction story for recombinant virus geeks and the rest of us.
Because Patty is nothing if not a medical RPer.

Comrade Chen we have a serious problem. Don’t tell me one of our bugs escaped confinement. Worse. One of theirs did. And it’s affecting the PLA (People’s Liberation Army). Some are turning into pacifists. It doesn’t kill them? No. But for our purposes it might as well. It’s a typical adenoassociated virus (AAV) like we […]

via A science fiction story (for the cognoscenti) — answer to the puzzle and a bit more — Chemiotics II


Strawberry Singh’s “My Zodiac Sign” Challenge (way late as usual, sorry)

Strawberry Singh, whose challenges are about the only ones I bother with in SL, back last year challenged us to compare ourselves to what the astrologers say we ought to be like.

Truth-tropic sort I am, even though I am late on this by over a year, here’s my entry:

Patricia de Chenier (angelpatty resident) August 16, 2018 at 1:57 pm

What is your Zodiac sign?:  My birthday is November eighth so I am in Scorpio

Do you believe in Astrology and read your horoscope often?:    No, from either a biologic or physics standpoint I find astrology highly implausible.

Strengths:   “Resourceful, brave, passionate, stubborn, a true friend”
I am resourceful, not especially brave, can be passionate and stubborn, and I hope I am a true friend

Weaknesses: “Distrusting, jealous, secretive, violent”
I take very little on trust, and do not consider that a weakness
I am not jealous
If I were secretive, you wouldn’t be reading this, would you?
I have been violent when the occasion called for it (once held someone at gunpoint who was in the process of murdering his sister until the police arrived to take him into custody), but apart from that incident, am not considered to be even disagreeable.

Scorpio likes: “Truth, facts, being right, longtime friends, teasing, a grand passion”
I like truth and facts. I am humbly grateful when someone can show me when I am wrong. longtime friends are treasures. I’m not fond of teasing, apart from very quiet irony. Passion, I do like.

Scorpio dislikes: “Dishonesty, revealing secrets, passive people”
Deliberate dishonesty which hurts others is a very strong dislike, but our true age,weight, and other details may be edited or withheld as needed.
I try very hard never to reveal a secret entrusted to me
I accept people as they are. “passive” is a bad name for someone’s personality, and not a particularly bright name, either.

The rest of that section merely recapitulates points gone over above.

Serenity Onsen, Chenier

Orcaflotta (who you doubtless know from her blog Thar She Blows!) and I recently discussed adding traditional Japanese bathhouses (known as onsen) on a recent page of her blogHer onsen is coming right along and mine’s… not your average onsen.

Serenity Onsen is a minimalist onsen designed for the County of Chenier, a women-only microstate.

Serenity Onsen wide shot

We provide a bathing experience to those visiting Chenier to relax and enjoy quiet (but fullfilling intimacy, not who are “conducting their blooming in the noise and whip of the whirlwind” (to quote Gwendolyn Brooks’ “The Second Sermon on the Warpland”).

I’ll expand on this description a little later.  You can get there from here:

http://maps.secondlife.com/secondlife/Triggerfish/163/34/22 (Women only, PLEASE)

Walk forward a little bit, and you see the actual hot tub that serves as our onsen :

Serenity Onsen very close-up.png

If you wish to do the entire bathhouse experience, you can wash either from a washbasin or a small bathtub in the enclosure.   A massage table and cozy rug are also available:

Serenity Onsen interior_001.png

Talk to you later!


For those of you who (like my friend Orca) visited my onsen and liked it, I made a change you may or may not appreciate. Both the tub for washing inside the bathhouse and the “Spring Onsen” hot tub for socializing and cuddling are now the designer’s “PG versions”, not their “Adult versions”.  The “adult” sex animations supplied with versions I first used are not there.

I did that because I and other people whose judgment I trust who’ve tried the tubs didn’t care for the kind of sex in the adult versions – all male-female sexual animations, which are out-of-theme for a women-only group, and too rough for many in the group (including me) to enjoy.  The fact that almost every one of those animations have vigorous pelvic thrusts or oral sex with something which is not a female body part decided me.

But my intrepid crew of test subjects and I find that 30 “cuddle” animations in the “PG” hot tub are entirely suited to sexual role-playing.  Some of them are the most erotic things I’ve ever seen in seven years of using scripted furniture in SL, and entirely suited to lesbian love-making.  Cary and I had our first onsen date without using any of the adult animations.  And we partied hard.

Update 2:

Serenity Onsen has graduated from a bath house and a quirky hot tub under a tree to “real onsen“!

It’s still less formal than other SL onsen, but is now centered around Tsuki no Mayu Hakata’s “Hinoki_Buro_No.5_ver.1.0”, a roomy onsen which fits nicely inside Wingsong’s “Beach House – Dojo v.2”, with plenty of room for bathing tub, wash basin and massage table.

Unlike the outside hot tub (“Spring Onsen” by Dysfunctionality), visible through the door, this one has traditional Japanese poses and room for at least four bathers (if everyone’s very friendly, we think eight bathers).

Now, you can have traditional onsen or more Westernized fun out in the tub under the tree – or one after the other!!

Omar Khayyam and the embryology of the cerebral cortex

The “moving finger” of embryonic neuron formation is the enzyme PRDM16, which acts on the protein histone H3 as radial glial cells proliferate from the ventricles of the developing brain to make its six layers of 80 billion neurons, connected by 150 trillion synapses. The DNA doesn’t code for that directly. Looks like it’s all that ol’debbil evolution. Again.

If you inhibit another histone-related enzyme, histone deacetylase, horrible birth defects happen during pregnancy.  But inhibit that enzyme in a cancer patient, and you can slow or stop some cancers from growing.  Two old-ish drugs work that way, valproic acid (used to treat epilepsy and manic-depressive disorder for years) and thalidomide (a tranquilizer that caused those horrible birth defects and only now is back in use to treat leprosy and is now in clinical trials for cancer).

We’re only now understanding how enzymes in the body do things we never suspected they would – the story of how histones interact with enzymes and short sequences of DNA is the “histone code”. The sequence of nucleotides in DNA doesn’t control it and isn’t long enough to control every single cell whose growth is governed by the histone code. We’re a long way from knowing very much about that.

Chemiotics II

“The moving finger writes; and, having writ, moves on”.  Did Omar Khayyam realize he was talking about the embryology of the human cerebral cortex?  Although apparently far removed from chemistry, embryology most certainly is not.  The moving finger in this case is an enzyme modifying histone proteins.

In the last post (https://luysii.wordpress.com/2018/06/04/marshall-mcluhan-rides-again/) I discussed how one site in the genome modified  the expression of a protein important in cancer (myc) even though it was 53,000 positions (nucleotides) away.  When stretched out into the usual B-form DNA shown in the text books this would stretch 1.7 microns or 17% of the way across the diameter of the usual spherical nucleus.  If our 3,200,000 nucleotide genome were chopped up into pieces this size some 60,000 segments would have to be crammed in.  Clearly DNA must be bent and wrapped around something, and that something is the nucleosome which is shaped like a fat…

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Relay for Life

I do NOT want you to join THIS club, Orca. Hoping your tests come out negative for cancer. Sincere hugs!

Thar She Blows!

As most of you might know I’m not much of a fan of the Relay for Life thingy since I find it highly hypocritical by the Big Pharma Corps to beg for donations in order to continue their research for a cure. These corporations are raking in billions of dollars, use all the dirty tricks in the book to avoid paying taxes and don’t give a flying wet towel about your life … or mine. It’s a shakedown dontcha think? In my eyes that’s highly sarcastic and inhumane. And it’s soooo very American. And that’s why I only half-heartedly support the RfL in Second Life.


And then I read Patricia de Chenier’s blog where she thanks all who relayed and I stumble about sentences like “a fight we never picked – with cancer”, and something in me goes Gulps. 😮 And I’m feeling vulnerable and weak and all…

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A special thankyou to all who relayed

Kimiko Lastchance is, like me, in a fight we never picked – with cancer. She also produces the SL Airmenship Blog, and in that blog talked about SL Relay for Life, a charitable event that, like others in Second Life, raises money from our half-a-million residents for the American Cancer Society. ACS helped me when I had to travel two states away for experimental cancer treatment, and it’s a worthy cause that helps many others, too. Thanks, Kimiko, for being part of the solution to the problem.

Second life Airmenship

It’s over again, and you all did an amazing job! On total Fly For life raised a grand total of L$362,263 that is over $ 2,000! For the ACS I always find it hard to sleep on the last Relay day wondering if I did enough the last two years I sat through Meetings for RFL with a bucket between my legs throwing up as I was sickened by my own fight against cancer a fight I have won twice and hopefully this time will be the last. And yes I did not do enough and I resolve to be more active next year. I have some exciting things in mind for next year. I hope you join me next year for the goal of blotting out the sun with our aircraft let them sail in the shade!

I am going to tell you a personal story that haunts me…

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Hoyt On Heinlein – A Forest Of Jungian* Knives

Here’s Sarah Hoyt, who was as profoundly influenced by the work of Robert Heinlein as I was. (More so, she’s selling copy!) In any case, she takes on all the neo-puritans who are trying to portray Heinlein as a cheesy, ’80s disco, dirty old man he never was. She’s a breath of fresh air.

According To Hoyt

As some of you know I got to read Learning Curve by William Patterson in Advanced Reading Copy format, and I was dissatisfied – through my own fault – with my blogging about it at Tor.com. (I was NOT dissatisfied with the book, which I think every Heinlein fan should read.) Not blaming anyone save myself, because I tend to get emotional when it comes to Heinlein. Frankly more so than I would expect. And one of the ways I fit the stereotype of the Latin female is that I am… excitable. At least that’s what my husband says.

I will start the serious Heinlein blogging next week, and hopefully do one post a week.

This one is sort of a general Heinlein blogging thing.

If you’re in Colorado Springs, and even if you’re not, you probably know that Cosine, the local con, has a panel on Heinlein every year…

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